Author's response to reviews Title: A single nucleotide polymorphism in TRAF1/C5 locus is associated with rheumatoid arthritis in a Han Chinese population Authors:

نویسندگان

  • Jin Zhu
  • Dingding Zhang
  • Fengxia Wu
  • Xiaoqi Liu
  • Lijun Wu
  • Bin Zhou
  • JIanping Liu
  • Fang Lu
  • Jian Liu
  • Ruijun Luo
  • Wubin Long
  • Minghui Yang
  • Xiaodan Wu
  • Yi Shi
  • Tong Wu
  • Ying Lin
  • Jiyun Yang
  • Guohua Yuan
  • Zhenglin Yang
  • Scott Edmunds
چکیده

Jin Zhu ([email protected]) Dingding Zhang ([email protected]) Fengxia Wu ([email protected]) Xiaoqi Liu ([email protected]) Lijun Wu ([email protected]) Bin Zhou ([email protected]) JIanping Liu ([email protected]) Fang Lu ([email protected]) Jian Liu ([email protected]) Ruijun Luo ([email protected]) Wubin Long ([email protected]) Minghui Yang ([email protected]) Shi Ma ([email protected]) Xiaodan Wu ([email protected]) Yi Shi ([email protected]) Tong Wu ([email protected]) Ying Lin ([email protected]) Jiyun Yang ([email protected]) Guohua Yuan ([email protected]) Zhenglin Yang ([email protected])

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Single Nucleotide Polymorphisms within Calcineurin-Encoding Genes are Associated with Response to Aerobic Training in Han Chinese Males

Calcineurin, which functions in calcium signaling, is expressed in skeletal and cardiac muscle and has been linked to sensitivity to muscle strength training. It is also proposed to contribute to individual aerobic endurance. To investigate the relationship between calcineurin-encoding genes and aerobic endurance traits, 126 young-adult Han Chinese males were enrolled in an aerobic exercise tra...

متن کامل

Armitage's trend test for genome-wide association analysis: one-sided or two-sided?

The importance of considering confounding due to population stratification in genome-wide association analysis using case-control designs has been a source of debate. Armitage's trend test, together with some other methods developed from it, can correct for population stratification to some extent. However, there is a question whether the one-sided or the two-sided alternative hypothesis is app...

متن کامل

Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China

Objective(s): This study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China).Materials and Methods: Polymerase chain reaction-sequence specific primers were used to detect HLA-Cw01–08 of 201 RA patients an...

متن کامل

A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis

BACKGROUND Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting approximately 1% of the population. The disease results from the interplay between an individual's genetic background and unknown environmental triggers. Although human leukocyte antigens (HLAs) account for approximately 30% of the heritable risk, the identities of non-HLA genes explaining the remainder of the genet...

متن کامل

Association of IL-10 rs1800896 (-1082 G/A) gene polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran

Background and objectives: Rheumatoid arthritis (RA) is a complex and systemic inflammatory disease in which the immune response is disturbed. Single nucleotide polymorphisms (SNPs) in the promoter regions of regulatory cytokines including interleukin-10 (IL-10) may lead to exacerbated immune response and increased risk of RA. Here, we aimed to assess the association of IL-10 -1082 (G/A) (rs180...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010